Shenzhen Wenzhi Bio-Technology Co.,Ltd
Shenzhen Wenzhi Bio-Technology Co.,Ltd
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Home>Products>Female Steroids>Purity 99% Women Bodybuilding Steroids Ethinylestradiol High Efficiency CAS 57

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  • Purity 99% Women Bodybuilding Steroids Ethinylestradiol High Efficiency CAS 57
  • Purity 99% Women Bodybuilding Steroids Ethinylestradiol High Efficiency CAS 57

Purity 99% Women Bodybuilding Steroids Ethinylestradiol High Efficiency CAS 57

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Product Details

CAS: 57-63-6 Molecular Weight: 296.41 Molecular Formula: C20H24O2
EINECS: N/A Assay: 99% Keywords: Female Steroids,Hormone Steroid, Female Acetate, Female Estradiol, Steroid Powder Mifepristone ,Steroid Hormone Pt 141, Steroid Ethisterone, Steroid Estrogen Norethisterone Enanthate, Female Hormone, Steroid Powder Meprednisone, Steroid Hormone Diethylstil

Product Description

Purity 99% Body Builder Female Steroids Ethinylestradiol CAS NO.: 57-63-6


Basic Information

Item Specification
CAS 57-63-6
Formula C20H24O2
Molecular Weight 296.41
EINECS N/A
Assay 99%

Description

Ethinyl estradiol, also sometimes written as 17α-ethinyl estradiol, ethinylestradiol, ethynyl estradiol, or ethinyl œstradiol, is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills and is one of the most commonly used medications for this purpose.

Transdermal ethinyl estradiol carries a greater risk of clot formation and venous thromboembolism than naturally occurring 17β-estradiol, which some have theorized to be related to different amounts of hepatic metabolism after absorption. The same contraindications and precautions apply for EE2 as with other estrogen medications.

Estinyl was a preparation of EE2 alone that was used for the management of menopausal symptoms and female hypogonadism.

EE2 is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication.

The major concern with unopposed estrogen (without progestogen) is of endometrial cancer.[citation needed] As such, the medication is generally prescribed with progesterone in the setting of birth control.


History


The first orally active semisynthetic steroidal estrogen, EE2 (17α-ethynylestradiol), the 17α-ethynyl analog of E2, was synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering AG in Berlin.

EE2 was approved by the FDA in the U.S. on June 25, 1943 and marketed by Schering as Estinyl. It was used for hormone replacement therapy in menopause, loss of menstruation, pain and cramping during menstruation, treatment of acne, prostate cancer, and breast cancer in elderly women.

The FDA withdrew approval of Estinyl effective June 4, 2004 at the request of Schering, who had discontinued marketing Estinyl.


Pharmacology


While E2 is readily absorbed when taken orally, it is also quickly inactivated by the liver. Substitution at C17 of the estrane steroid with an ethinyl group served to provide an estrogen that is much more resistant to degradation and paved the way for the development of oral contraceptives.

EE2 is absorbed in the small intestine and reaches a serum peak about 2 hours later. It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme. EE2 and its metabolites are excreted with the bile. Due to the effect of enterohepatic circulation a second peak is seen several hours later. Individually, wide variations exist in the overall absorption process, and can be further modified by drugs (i.e. antibiotics) that affect the enterohepatic circulation or liver enzymes. In circulation EE2 is almost fully bound to plasma albumin. It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine, in part as glucuronide and sulfate conjugate.

EE2 is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives. Over time, formulations have decreased the EE2 dose from as high as 100 μg to as low as 10 μg in LoLoestrin Fe.


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