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White Pharmaceutical Raw Material Amorolfine Hydrochloride / Amorolfine HCl CAS
- Pharmaceutical Raw Material Amorolfine Hydrochloride / Amorolfine HCl
CAS 106614-68-0
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Product Details
| CAS: | 106614-68-0 | Grade: | USP/BP | Assay: | 99% |
| Molecular Formula: | C21H35NO HCl | Molecular Weigh: | 353.97 | Character: | white powder |
Product Description
99% Pharmaceutical Raw Material Amorolfine Hydrochloride / Amorolfine HCl CAS 106614-68-0
Basic information
| Cas No. | 78613-38-4 |
| Product ID | A5056 |
| Product Name | Amorolfine Hydrochloride |
| Chemical Name | (2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine hydrochloride |
| Formula | C21H35NO HCl |
| Formula Wt. | 353.97 |
| Melting Point | 204-206 |
| Purity | >98.5% |
| Solubility | Slightly soluble in water, less soluble in HCl solution |
| Store Temp | Ambient |
Description:
Amorolfine is an antifungal compound that prevents ergosterol synthesis through the inhibition of sterol 14α-demethylase. Amorolfine increases release of prostaglandin D2 metabolites, inhibiting release of thromboxane B2 (TxB2), activation of NF-κB, and production of thymic stromal lymphopoetin; as a result, inflammation in atopic dermatitis models is decreased.
COA
TEST ITEM |
LIMT |
TEST RESULTS |
APPEARANCE |
WHITE OR ALMOST WHITE,HYGROSCOPLE,CRYSTALLINE POWDER |
CONFORMS |
SOLUBILITY |
SLIGHTLY SOLUBLE IN WATER,FREELY SOLUBLE IN METHANOL,SOLUBLE IN ACETONE |
COMPLIES |
IDENTIFICATION |
TO COMPLY |
COMPLIES |
APPEARANCE OF SOLUTION |
THE SOLUTION IS CLEAR AND COLORLESS |
COMPLIES |
RELATED SUBSTANCES % |
IMPURITY A≤0.4 IMPURITY B≤0.3 IMPURITY C≤0.1 UNSPECIFIED IMPURITIES≤0.1 TOTAL IMPURITY≤0.6 |
0.3 NIL NIL 0.02 0.32 |
HEAVY METALS % |
≤0.001 |
<0.001 |
LOSS ON DRYING % |
≤0.5 |
0.18 |
SULPHATED ASH % |
≤0.1 |
<0.1 |
ASSAY (ON DRY BASIS) % |
99.0-101.0 |
99.68 |
GRANULE SIZE |
180 MICRON MAX |
CONFORMS |
CONCLUSION |
CONFORMS TO EP5.6 |
|
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White Pharmaceutical Raw Material Amorolfine Hydrochloride / Amorolfine HCl CAS Images |
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