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Home>Products>Pharmaceutical Raw Material>99% Purity Pharma Grade Isotretinoin Pharmaceutical Raw Material CAS 4759-48-2

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  • 99% Purity Pharma Grade Isotretinoin Pharmaceutical Raw Material CAS 4759-48-2
  • 99% Purity Pharma Grade Isotretinoin Pharmaceutical Raw Material CAS 4759-48-2

99% Purity Pharma Grade Isotretinoin Pharmaceutical Raw Material CAS 4759-48-2

  • Isotretinoin Pharmaceutical Raw Material
  • CAS 4759-48-2

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Product Details

CAS: 4759-48-2 Grade: USP/BP Assay: 99%
Molecular Formula: C20H21ClO4 Molecular Weigh: 360.84 Character: white powder

Product Description

99% Purity Pharma Grade Isotretinoin Pharmaceutical Raw Material CAS 4759-48-2 for Treatment of Severe Acne Embolism

Basic information

Product Name:Isotretinoin
Synonyms:13-cis-ra;13-cis-retinoicaci;13-ra;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
CAS:4759-48-2
MF:C20H28O2
MW:300.44
EINECS:225-296-0
Product Categories:Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;API;BUSPAR;Other APIs;intermediates
Mol File:4759-48-2.mol


Chemical Properties

mp172-175 °C(lit.)
storage temp.−20°C
Water Solubilityinsoluble
Stability:Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference4759-48-2(CAS DataBase Reference)
EPA Substance Registry SystemRetinoic acid, 13-cis-(4759-48-2)



Isotretinoin Description
1,Isotretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia, and is sold for this indication by Roche under the brand name Vesanoid. It is also available as a generic.
2 Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia gene.

This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia. ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.
Isotretinoin Function

1.Isotretinoins main indication is for the treatment of severe cystic acne vulgaris. Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.
2.It is also somewhat effective for hidradenitis suppurativa and some cases of severe acne rosacea. It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.
3.Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used due to potentially severe side effects. In a small-scale study, low dose oral isotretinoin showed considerable efficacy;
4.Isotretinoin may represent an efficacious and safe alternative systemic form of therapy for RCA of the cervix. Not many studies have been conducted to further confirm its effectiveness. In most countries this therapy is currently unapproved and only used if other therapies failed.
COA

Product nameIsotretinoin (13-cis Vitamin A acid)
CAS No.4759-48-2Packing100G/25KG
Date of manufacturing2th, July, 2016Shelf life1th, July, 2018
StandardUSP34
ITEMSSPECIFICATIONRESULTS
AppearanceYellow or orange crystalline powderComplies
IdentificationCompliesComplies
Loss on dryingNot more than 0.5%0.05%
Residue on ignitionNot more than 0.1%0.02%
Heavy metalsNot more than 0.002%<0.002
TretinoinNot more than 1.0%0.1%
Assay98%~102.0%99.8%
ConclusionQualified


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