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Home>Products>Pharmaceutical Raw Material>99% Antihypotensive Pharmaceutical Raw Material Etilefrine Hydrochloride

99% Antihypotensive Pharmaceutical Raw Material Etilefrine Hydrochloride
- Haiwen Pharmaceutical Raw Material Etilefrine Hydrochloride
Pharmaceutical Raw Material Etilefrine Hydrochloride
- China
- GMP,SGS,UKAS,ISO
- Negotiable
- Negotiable
- foil bag or as your requirement
- Within 1-2 working days upon receipt payment
- T/T, Western union, MoneyGram
- 1000kgs/month
-
Shenzhen Wenzhi Bio-Technology Co.,Ltd2020-07-10 09:46:19
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Product Details
CAS: | 943-17-9 | Grade: | USP/BP | Assay: | 99% |
MF: | C10H16ClNO2 | Molecular Weigh: | 217.69 | Character: | white powder |
name: | Etilefrine hydrochloride | alias: | Etilefrine hcl |
Product Description
99% Antihypotensive Pharmaceutical Raw Material Etilefrine Hydrochloride Phetanol CAS: 943-17-9
Etilefrine hydrochloride Basic information
Product Name: Etilefrine hydrochloride
CAS: 943-17-9
MF: C10H16ClNO2
MW: 217.69
EINECS: 213-398-8
Appearance : White powders
Usage : For the treatment of hypotension, with significant positive muscle strength, increased cardiac output, increased blood pressure .
Etilefrine hydrochloride Description
Etilefrine is a cardiac stimulant used as an antihypotensive. It is a sympathomimetic amine of the 3-hydroxy-phenylethanolamine series used in treating orthostatic hypotension of neurological, cardiovascular, endocrine or metabolic origin. Intravenous infusion of this compound increases cardiac output, stroke volume, venous return and blood pressure in man and experimental animals, suggesting stimulation of both α and β adrenergic receptors. However, in vitro studies indicate that etilefrine has a much higher affinity for β1 (cardiac) than for β2 adrenoreceptors .
Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Peripheral vascular resistance falls during the infusion of 1-8 mg etilefrine but begins to rise at higher dosage. Marked falls in pulse rate, cardiac output, stroke volume and peripheral bloodflow, accompanied by rises in mean arterial pressure, occur when etilefrine is infused after administration of intravenous propranolol 2,5 mg. These findings indicate that etilefrine has both β1 and α1 adrenergic effects in man .
COA
TEST ITEM | SPECIFICATION | RESULTS |
Appearance | Almost white powder | Almost white powder |
Identification | FT-IR,HPLC,NMR,Mass | Confirm |
Loss on drying | 1.0%max | 0.42% |
Melting point | 135°Cmin | 145.5°C |
Residue on ignition | 0.5% | 0.13% |
Heavy metals | 20ppmmax | Confirm |
Iron | 20ppm | Confirm |
Bacteria endotoxins | 0.4 USP EU/mg | 0.2 EU/mg |
Microbial Limits | ||
Total aerobic microbial count | 100 cfu/g max | Confirm |
Staphylococcus aureus | Absence | Absence |
Pseudomonas aeruginosa | Absence | Absence |
Salmonella species | Absence | Absence |
Escherichia Coli | Absence | Absence |
Impurities | ||
Any other single impurity | 0.3% max | Confirm |
Total impurities | 1.0% max | 0.66% |
Assay | 98.0%-102.0% | 99.53% |
Conclusion | The lot meets the specifications |
.
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