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Home>Products>Pharmaceutical Raw Material>99% Antihypotensive Pharmaceutical Raw Material Etilefrine Hydrochloride

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  • 99% Antihypotensive Pharmaceutical Raw Material Etilefrine Hydrochloride
  • 99% Antihypotensive Pharmaceutical Raw Material Etilefrine Hydrochloride

99% Antihypotensive Pharmaceutical Raw Material Etilefrine Hydrochloride

  • Haiwen Pharmaceutical Raw Material Etilefrine Hydrochloride
  • Pharmaceutical Raw Material Etilefrine Hydrochloride

  • China
  • GMP,SGS,UKAS,ISO
  • Negotiable
  • Negotiable
  • foil bag or as your requirement
  • Within 1-2 working days upon receipt payment
  • T/T, Western union, MoneyGram
  • 1000kgs/month
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Shenzhen Wenzhi Bio-Technology Co.,Ltd

Shenzhen Wenzhi Bio-Technology Co.,LtdChina

  • Shenzhen Wenzhi Bio-Technology Co.,Ltd2020-07-10 09:46:19
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Product Details

CAS: 943-17-9 Grade: USP/BP Assay: 99%
MF: C10H16ClNO2 Molecular Weigh: 217.69 Character: white powder
name: Etilefrine hydrochloride alias: Etilefrine hcl

Product Description

99% Antihypotensive Pharmaceutical Raw Material Etilefrine Hydrochloride Phetanol CAS: 943-17-9

Etilefrine hydrochloride Basic information

Product Name: Etilefrine hydrochloride
CAS: 943-17-9
MF: C10H16ClNO2
MW: 217.69
EINECS: 213-398-8
Appearance : White powders
Usage : For the treatment of hypotension, with significant positive muscle strength, increased cardiac output, increased blood pressure .


Etilefrine hydrochloride Description

Etilefrine is a cardiac stimulant used as an antihypotensive. It is a sympathomimetic amine of the 3-hydroxy-phenylethanolamine series used in treating orthostatic hypotension of neurological, cardiovascular, endocrine or metabolic origin. Intravenous infusion of this compound increases cardiac output, stroke volume, venous return and blood pressure in man and experimental animals, suggesting stimulation of both α and β adrenergic receptors. However, in vitro studies indicate that etilefrine has a much higher affinity for β1 (cardiac) than for β2 adrenoreceptors .

Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Peripheral vascular resistance falls during the infusion of 1-8 mg etilefrine but begins to rise at higher dosage. Marked falls in pulse rate, cardiac output, stroke volume and peripheral bloodflow, accompanied by rises in mean arterial pressure, occur when etilefrine is infused after administration of intravenous propranolol 2,5 mg. These findings indicate that etilefrine has both β1 and α1 adrenergic effects in man .

COA

TEST ITEM SPECIFICATION RESULTS
Appearance Almost white powder Almost white powder
Identification FT-IR,HPLC,NMR,Mass Confirm
Loss on drying 1.0%max 0.42%
Melting point 135°Cmin 145.5°C
Residue on ignition 0.5% 0.13%
Heavy metals 20ppmmax Confirm
Iron 20ppm Confirm
Bacteria endotoxins 0.4 USP EU/mg 0.2 EU/mg
Microbial Limits
Total aerobic microbial count 100 cfu/g max Confirm
Staphylococcus aureus Absence Absence
Pseudomonas aeruginosa Absence Absence
Salmonella species Absence Absence
Escherichia Coli Absence Absence
Impurities
Any other single impurity 0.3% max Confirm
Total impurities 1.0% max 0.66%
Assay 98.0%-102.0% 99.53%
Conclusion The lot meets the specifications



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